闫秀英,吴灶和,简纪常,鲁义善,孙修勤

• 1:广东省水产经济动物病原生物学及流行病学重点实验室广东海洋大学
• 2:海洋生态研究中心国家海洋局第一海洋研究所

摘要(Abstract)：

LCDV-cn是分离自中国养殖牙鲆的淋巴囊肿病病原,给中国牙鲆养殖业带来了严重危害。通过PCR、克隆和测序,获得了LCDV-cn部分基因的序列,证明LCDV-cn与LCDV-C的基因组序列是一致的。比较基因组学分析发现,LCDV-cn基因组中有137个ORF是其独有的、与LCDV-1及其它虹彩病毒无同源区域。对LCDV-cn基因组进行生物信息学分析发现,在LCDV-cn独有的ORF中,有的编码与宿主同源的蛋白,有的编码与DNA复制相关的蛋白,某些ORF编码的蛋白含有跨膜区等。LCDV-cn的独有基因或许对其毒力和宿主范围有关。

关键词(KeyWords)： 淋巴囊肿病毒中国分离株LCDV-cn;比较基因组学;生物信息学

Abstract:

Keywords:

基金项目(Foundation): 国家高技术研究发展计划项目(2006AA100309)资助

作者(Author): 闫秀英,吴灶和,简纪常,鲁义善,孙修勤

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