二噁英类化合物对斑马鱼CYP1 A毒理作用的研究新进展
聂芳红,刘连平,陈进军,林红英,杨蓉,谢英明
摘要(Abstract):
关键词(KeyWords): CYP1 A;二噁英类化合物;毒理学;斑马鱼
基金项目(Foundation): 广东省自然科学基金项目(05011789);; 广东海洋大学SCI刊源作者基金(0412130)
作者(Author): 聂芳红,刘连平,陈进军,林红英,杨蓉,谢英明
参考文献(References):
- [1]Wu Q,Ohsako S,Baba T,et al.Effects of 2,3,7,8-tetra-chlorodibenzo-p-dioxin(TCDD)on preimplantation mouseembryos[J].Toxicol,2002,174:119-129.
- [2]Poland A,Kuntson J K.2,3,7,8-Tetrachlorodibenzo-p-dioxinand related halogenated aromatic hydrocarbons of the mecha-nism of toxicity[J].Auun Rev Pharmacol Toxicol,1982,22:517-541.
- [3]Dong W,Teraoka H,Tsujimoto Y,et al.Role of Aryl hydor-ocarbon receptor in mesencephalic circulation failure and apop-tosis in zebrafish embryos exposed to 2,3,7,8-tetrachlorod-ibenxo-p-dioxin[J].Toxicol Sci,2004,77:109-116.
- [4]Chen J J,Chen G S,Bunce N J.Inhibition of CYP 1A2 de-pendent-MROD activity in rat liver microsomes:An explana-tion of the hepatic sequestration of a limited subset of haloge-nated aromatic hydrocarbons[J].Environ Toxicol,2003,18(2):115-119.
- [5]Incardona JP,Day HL,Collier TK,et al.Developmental tox-icity of 4-ring polycyclic aromatic hydrocarbons in zebrafish isdifferentially dependent on AH receptor isoforms and hepaticcytochrome P4501A metabolism[J].Toxicol Appl Pharma-col,2006,217(3):308-321.
- [6]Billiard SM,Timme-Laragy AR,Wassenberg DM,et al.Therole of the aryl hydrocarbon receptor pathway in mediatingsynergistic developmental toxicity of polycyclic aromatic hy-drocarbons to zebrafish[J].Toxicol Sci,2006,92(2):526-536.
- [7]孙智慧,贾顺姬,孟安明.斑马鱼:在生命科学中畅游[J].生命科学,2006,18(5):431-436.
- [8]Adrian J H,Hiroki T,Warren H,et al.Review Zebrafish asa Model Vertebrate for Investigating Chemical Toxicity[J].Toxicol Sci,2005,86(1):6-19.
- [9]Teraoka H,Dong W,Hiraga T.Zebrafish as a novel experi-mental model for developmental toxicology[J].Congenital a-nomalies,2003,43(2):123-32.
- [10]鲍剑冰,唐翔宇.水体中PCDD/Fs生物标示器的研究进展[J].云南环境科学,2004,23(3):1-7.
- [11]成建华.环境中的二噁英及其对健康的影响[J].中华预防医学杂志,2000,34(6):365-368.
- [12]刘泰民.二噁英及其对人体的毒性和预防[J].预防医学情报杂志,2000,16(12):121-122.
- [13]杨永滨,郑明辉,刘征涛.二噁英类毒理学研究新进展[J].生态毒理学报,2006,1(2):106-111.
- [14]Cantrell SM,Joy Schlezinger J,Stegeman JJ,et al.Correla-tion of 2,3,7,8-tetrachlorodibenzo--pdioxin-induced apop-totic cell death in the embryonic vasculature with embryotox-icity[J].Toxicol Appl Pharmacol,1998,148,24-34.
- [15]Cantrell SM,Lutz LH,Tillitt DE,et al.Embryotoxicity of2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD):the embry-onic vasculature is a physiological target for TCDD-inducedDNA damage and apoptotic cell death in Medaka(Oriziaslatipes)[J].Toxicol Appl Pharmacol,1996,141:23-34.
- [16]董武,魏强,寺冈宏树,等.二噁英诱发斑马鱼初期胚的循环系统障碍[J].中国实验动物学报,2002,10(2):69-72.
- [17]Perdew G H.Association of the Ah receptor with the 90kDaheat shock protein[J].Bio Chem,1988,263:13802-13805.
- [18]霍传林,王菊英,韩庚辰,等.鱼体内EROD活性对多氯联苯类的指示作用[J].海洋环境科学,2002,21(1):5-8.
- [19]Voelker D,Vess C,Tillmann M,et al.Differential gene ex-pression as a toxicant-sensitive endpoint in zebrafish embryosand larvae[J].Aquat Toxicol,2007,81(4):355-364.
- [20]刘伟成,李明云.斑马鱼及其人工繁殖[J].水利渔业,2006,26(1):31,39-40.
- [21]Streisinger G,Walker C,Dower N,et al.Production ofclones of homozygous diploid zebrafish(Brachydanio rerio)[J].Nature,1981,291(5813):293-296.
- [22]Parng C.In vivo zebra fish assays for toxicity testing[J].Curr Opin Drug Discov Devel,2005,8(1):100-106.
- [23]Carney SA,Prasch AL,Heideman W,et al.Understandingdioxin developmental toxicity using the zebrafish model[J].Birth Defects Res A Clin Mol Teratol,2006,76(1):7-18.
- [24]Vitozzi L,De Angelis G.A critical review of comparative a-cute toxicity data on freshwater fish[J].Aquat Toxicol,1991,19:167-174.
- [25]Ensenbach U,Nagel R.Toxicity of complex chemical mix-tures:acute and long-term effects on different life stages of ze-brafish[J].Ecotoxicol Environ Saf,1995,30:151-157.
- [26]Prasch AL,Teraoka H,Carney S C,et al.Aryl hydrocarbonreceptor2 mediates 2,3,7,8-tetrachlorodibenzo-p-dioxin de-velopmental toxicity in zebrafish[J].Toxicol Sci,2003,76:138-150.
- [27]Teraoka H,Dong W,Ogawa S,et al.2,3,7,8-Tetrachlo-rodibenzo-p-dioxin toxicity in the zebrafish embryo:alteredregional blood flow and impaired lower jaw development[J].Toxicol Sci,2002,65:192-199.
- [28]Cook P M,Robbins J A,Endicott D D,et al.Effects of arylhydrocarbon receptor-mediated early life stage toxicity on laketrout populations in Lake Ontario during the 20thcentury[J].Environ Sci Techno,2003,l37:3864-3877.
- [29]Carvan M J,Dalton T P,Stuart G W et al.Transgenic ze-brafish as sentinels for aquatic pollution[J].Ann NY AcadSci,2000,919:133-147.
- [30]Carvan M J,Sonntag D M,Cmar C B,et al.Oxidative stressin zebrafish cells;Potential utility of transgenic zebrafish as adeployable sentinel for site hazard ranking[J].Sci Total En-viron,2001,274:183-196.
- [31]Sumanas S,Lin S.Zebrafish as a model system for drug tar-get screening and validation[J].ARGETS,2004,3,(3):121-123.
- [32]Kuiper R V,Murk A J,Leonards PE,et al.In vivo and invitro Ah-receptor activation by commercial and fractionatedpentabromodiphenylether using zebrafish(Danio rerio)andthe DR-CALUX assay[J].Aquat Toxicol,2006,79(4):366-375.
- [33]Herbomel P,Thisse B,Thisse C.Ontogeny and behaviour ofearly macrophages in the zebrafish embryo[J].Develop-ment,1999,126(17):3735-3745.
- [34]Korfsmeier K H.PCNA in the ovary of zebrafish[J].ActaHistochem,2002,104:73-76.
- [35]Cole L K,Ross L S.Apoptosis in the developing zebrafishembryo[J].Dev Biol,2001,246:123-142.
- [36]Miranda C L,Chung W G,Wang-Buhler J L,et al.Compar-ative in vitro metabolism of benzo[a]pyrene by recombinantzebrafish CYP1A and liver microsomes from beta-naphthofla-vone-treated rainbow trout[J].Aquat Toxicol,2006,80(2):101-108.
- [37]魏艳,王克坚,杨明,等.海水养殖真鲷肝CYP1A基因的克隆与表达[J].厦门大学学报(自然科学版),2006,45(增刊):190-193.
- [38]Carney S A,Peterson R E,Heideman W.2,3,7,8-Tetra-chlorodibenzo-p-dioxin activation of the aryl hydrocarbon re-ceptor/aryl hydrocarbon receptor nuclear translocator path-way causes developmental toxicity through a CYP1A-inde-pendent mechanism in zebrafish[J].Mol Pharmacol,2004,66:512-521.[39]Hornung M W,Spitsbergen J M,PetersonR E.2,3,7,8-Tetrachlorodibenzo-p-dioxin alters cardiovas-cular and craniofacial development and function in sac fry ofrainbow trout(Oncorhynchus mykiss)[J].Toxicol Sci,1999,47:40-51.
- [40]Antkiewicz D S,Burns C G,Carney SA.et al.Heart mal-formation is an early response to TCDD in embryonic ze-brafish[J].Toxicol Sci,2005,84:368-377.
- [41]Whyte J J,Jung R E,Schmitt C J,et al.Ethoxyresorufin-O-deethylase(EROD)activity in fish as a biomarker of chemi-cal exposure[J].Crit Rev Toxicol,2000,(4):347-570.
- [42]Finn R N.The physiology and toxicology of salmonid eggsand larvae in relation to water quality criteria[J].AquatToxicol,2007,81(4):337-354.
- [43]Rowlands J C,Gustafsson J A.Aryl hydrocarbon receptor-mediated signal transduction[J].Crit Rev Toxicol,1997,27(2):109-34.
- [44]Zodrow J M,Stegeman J J,Tanguay RL.Histological analy-sis of acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD)in zebrafish[J].Auqat Toxicol,2004,66(1):25-38.
- [45]Evans B R,Karchner S I,Franks D G,et al.Duplicate arylhydrocarbon receptor repressor genes(ahr1 and ahr2)in thezebrafishDanio rerio:structure,function,evolution,andAHR-dependent regulation in vivo[J].Arch Biochem Bio-phys,2005,441(2):151-67.