王昊印,张才,张永平,赵帅,李康伟,杨隆恩,宋采

• 1:广东海洋大学食品科技学院
• 2:广东海洋大学海洋深圳研究院

摘要(Abstract)：

【目的】比较二十二碳六稀酸(DHA)和二十碳五稀酸(EPA)改善慢性不可预测温和应激(CUMS)诱导的大鼠抑郁样行为的作用机制。【方法】应用糖水偏好实验测定糖水偏好度,强迫游泳实验测定不动时间,荧光定量PCR检测杏仁核脑源性神经营养因子(BDNF)、其受体酪氨酸激酶受体(TrKB)和神经营养素(p75NTR)基因表达。【结果】与对照组相比,CUMS组大鼠糖水偏好度、BDNF和TrKB基因表达显著降低(P﹤0.05),而不动时间和p75NTR基因表达显著升高(P﹤0.05);给予DHA和EPA喂食治疗,可显著改善CUMS诱发的大鼠快感缺乏,绝望行为以及BDNF和TrKB的表达(P﹤0.05);DHA提高BDNF的表达作用显著优于EPA,而EPA对降低不动时间和p75NTR的表达作用显著优于DHA(P﹤0.05)。【结论】DHA和EPA通过调控不同基因表达改善CUMS诱导的抑郁样行为变化。

关键词(KeyWords)： 抑郁症;慢性不可预见温和应激;DHA;EPA;神经营养因子

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(81171118,81471223);; 湛江市科技攻关计划项目“脑健康海洋药物与营养品重点实验室”

作者(Author): 王昊印,张才,张永平,赵帅,李康伟,杨隆恩,宋采

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