李舒蕊,张才,张理强,殷静雯,颜海锋,张永平,赵帅,宋采

• 1:广东海洋大学食品科技学院
• 2:湛江市第三人民医院
• 3:广东医科大学附属医院
• 4:广东海洋大学深圳研究院

摘要(Abstract)：

【目的】研究二十二碳五烯酸(Docosapentaenoicacid,DPA)对精神分裂症患者外周血淋巴细胞的活性及细胞内单胺类神经递质的调节作用。【方法】将正常人和病人的外周血淋巴细胞分为对照组、病人组、对照+DPA组(0～200μmol/L)、病人+DPA组(150μmol/L),用DPA处理细胞48 h。用CCK8法检测细胞存活率,用高效液相色谱法检测血浆中多巴胺及其代谢物的含量,检测淋巴细胞中去甲肾上腺素、多巴胺、5-羟色胺和代谢物的含量。【结果】与对照组相比,精神分裂症患者外周血淋巴细胞存活率下降,血浆中的多巴胺(DA)及其代谢产物二羟苯乙酸(DOPAC)含量上升,淋巴细胞中的多巴胺与其代谢产物、5-羟色胺(5-HT)与其代谢物5-羟吲哚乙酸(5-HIAA)的含量显著下降,DA/DOPAC、5-HT/5-HIAA比值显著升高,去甲肾上腺素代谢物的含量显著下降。DPA可以显著提高淋巴细胞的存活率,提高多巴胺、5-羟色胺及其代谢物的含量,降低DA/DOPAC、5-HT/5-HIAA比值,提高去甲肾上腺素代谢物的含量。【结论】DPA可以提高精神分裂症患者外周血淋巴细胞的存活率,调节单胺类神经递质的含量。

关键词(KeyWords)： 二十二碳五烯酸(DPA);精神分裂症;淋巴细胞;神经递质

Abstract:

Keywords:

基金项目(Foundation): 广东省应用型科技研发专项（2016B020235001）;; 湛江市科技计划项目（2018A01045）

作者(Author): 李舒蕊,张才,张理强,殷静雯,颜海锋,张永平,赵帅,宋采

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