罗理,王伟利,姜兰,谭爱萍,邓玉婷,赵飞

• 1:中国水产科学研究院珠江水产研究所农业部渔药创制重点实验室

摘要(Abstract)：

在水温28℃条件下,以12 mg/kg剂量对罗非鱼单次口服给药,采用HPLC方法测定不同时间实验鱼肝脏和肾脏中的药物水平,分析氟苯尼考在罗非鱼肝、肾组织的吸收及消除规律。结果显示,肝脏和肾脏中的药动学参数均符合药动学一室模型,肝脏的药物消除速度快于肾脏,消除半衰期T1/2β分别为4.89 h和15.93 h;药物在肝脏的Tmax为5.43 h,吸收峰值为4.84μg/g;59 h后肝、肾组织中的药物含量均低于0.8μg/g。取12 mg/kg剂量连续给药7 d的实验鱼肝、肾组织,进行组织学观察,结果显示,给药组罗非鱼的肝、肾组织均未出现病理性变化。此外,氟苯尼考对6株罗非鱼常见病原菌的体外抑菌实验中,最小抑菌浓度(MIC)均≤4 mg/L,表明常用剂量氟苯尼考在罗非鱼体内消除快、残留少且不造成组织损伤,对常见病原菌具有良好的抑菌效果。

关键词(KeyWords)： 罗非鱼;氟苯尼考;消除半衰期;一室模型;病理组织学变化;最小抑菌浓度

Abstract:

Keywords:

基金项目(Foundation): 公益性行业(农业)科研专项(201203085);; 广东省科技计划项目(2011B020307001)

作者(Author): 罗理,王伟利,姜兰,谭爱萍,邓玉婷,赵飞

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