代谢组学在水产品品质研究中的应用进展Progress in Application of Metabolomics in the Study of Aquatic Product Quality
李国道,徐昙烨,朱丹妮,刘峰,齐琳,刘俊荣
摘要(Abstract):
代谢组学的兴起使其在食品科学领域得到广泛应用,同时为研究水产品品质变化及其分子机理提供了新的方法。本文介绍了代谢组学的发展、研究流程和方法,综述了代谢组学在水产品流通链全过程(养殖、捕捞处置、储运、加工)中的研究进展,并展望了代谢组学技术在水产品流通链下品质评价与变化机理研究的应用前景,可为代谢组学在水产品品质的研究提供科学思路。
关键词(KeyWords): 代谢组学;水产品;品质;应用进展
基金项目(Foundation): 国家自然科学基金(32201926);; 大连市高层次人才创新计划(2021RQ097)
作者(Author): 李国道,徐昙烨,朱丹妮,刘峰,齐琳,刘俊荣
参考文献(References):
- [1]农业农村部渔业渔政管理局,全国水产技术推广总站,中国水产学会. 2022中国渔业统计年鉴[M].北京:中国农业出版社, 2022.
- [2] LI T T, WANG D F, LIU N, et al. Inhibition of quorum sensing-controlled virulence factors and biofilm formation in Pseudomonas fluorescens by cinnamaldehyde[J]. International Journal of Food Microbiology, 2018, 269:98-106.
- [3] CASTRO-PUYANA M, PéREZ-MíGUEZ R, MONTERO L,et al. Application of mass spectrometry-based metabolomics approaches for food safety, quality and traceability[J].TrAC Trends in Analytical Chemistry, 2017, 93:102-118.
- [4] SAMUELSSON L M, JOAKIM LARSSON D G. Contributions from metabolomics to fish research[J]. Molecular Bio Systems,2008, 4(10):974-979.
- [5] CAPOZZI F, BORDONI A. Foodomics:a new comprehensive approach to food and nutrition[J]. Genes&Nutrition, 2013,8(1):1-4.
- [6] VRZAL T, OL?OVSKáJ. Sensomics-basic principles and practice[J]. Kvasny Prumysl, 2019, 65(5):166-173.
- [7] RONNINGEN I, MILLER M, XIA Y L, et al. Identification and validation of sensory-active compounds from data-driven research:a flavoromics approach[J]. Journal of Agricultural and Food Chemistry, 2018, 66(10):2473-2479.
- [8] NICHOLSON J K, WILSON I D. Opinion:understanding'global'systems biology:metabonomics and the continuum of metabolism[J]. Nature Reviews Drug Discovery, 2003, 2(8):668-676.
- [9]李锐,孙祖莉,杨贤庆,等.代谢组学在水产品品质与安全中的研究进展[J].生物技术通报, 2020, 36(11):155-163.
- [10] NICHOLSON J K, TIMBRELL J A, SADLER P J. Proton NMR spectra of urine as indicators of renal damage. Mercuryinduced nephrotoxicity in rats[J]. Molecular Pharmacology,1985, 27(6):644-651.
- [11] DETTMER K, ARONOV P A, HAMMOCK B D. Mass spectrometry-based metabolomics[J]. Mass Spectrometry Reviews, 2007, 26(1):51-78.
- [12]仪莹,孙莹璐,王道平,等.植物代谢组学中几种重要的次生代谢物液质分析技术研究进展[J].生物工程学报,2022, 38(10):3674-3681.
- [13] WANG D H, GREENWOOD P, KLEIN M S. Deep learning for rapid identification of microbes using metabolomics profiles[J]. Metabolites, 2021, 11(12):863.
- [14] SONG J Y, XIANG S, YANG Y, et al. Assessment of follicular fluid metabolomics of polycystic ovary syndrome in kidney yang deficiency syndrome[J]. European Journal of Integrative Medicine, 2019, 30:100944.
- [15] WANG J, YUAN Z M, KONG H W, et al. Exploring the mechanism of rhizoma coptidis in treating type II diabetes mellitus based on metabolomics by gas chromatography-mass spectrometry[J]. Chinese Journal of Chromatography, 2012,30(1):8-13.
- [16]孙祥瑞,张淼,孔令强,等.代谢组学在食品科学与工程领域的研究进展[J].中国食品添加剂, 2021, 32(9):175-181.
- [17]林嘉意,谢炬,朱越平,等.代谢组学及其在环境毒理学中的应用[J].生物技术进展, 2022, 12(5):683-689.
- [18] XU Y J, WANG C S, HO W E, et al. Recent developments and applications of metabolomics in microbiological investigations[J]. TrAC Trends in Analytical Chemistry, 2014, 56:37-48.
- [19]安莉,汪红,马婧玮,等.基于核磁共振代谢组学分析不同品种草莓的化学成分差异[J].食品安全质量检测学报, 2020, 11(14):4750-4756.
- [20]孙慧敏,张婷,李震宇,等.基于~1H-NMR代谢组学的柴胡醋制前后的毒性作用比较研究[J].中国中药杂志,2022, 47(19):5224-5234.
- [21]徐婧,田亚平,陈艳华,等.代谢组学血浆样品前处理及其快速高分辨液相色谱-质谱分析方法研究[J].分析化学, 2011, 39(12):1793-1797.
- [22] TIAN H, LAM S M, SHUI G H. Metabolomics, a powerful tool for agricultural research[J]. International Journal of Molecular Sciences, 2016, 17(11):1871.
- [23] GARCIA D E, BAIDOO E E, BENKE P I, et al. Separation and mass spectrometry in microbial metabolomics[J]. Current Opinion in Microbiology, 2008, 11(3):233-239.
- [24] HENDRIKS M M W B, VAN EEUWIJK F A, JELLEMA R H, et al. Data-processing strategies for metabolomics studies[J]. TrAC Trends in Analytical Chemistry, 2011, 30(10):1685-1698.
- [25] FIEHN O. Combining genomics, metabolome analysis, and biochemical modelling to understand metabolic networks[J].Comparative and Functional Genomics, 2001, 2(3):155-168.
- [26] LINDON J C, HOLMES E, NICHOLSON J K. Pattern recognition methods and applications in biomedical magnetic resonance[J]. Progress in Nuclear Magnetic Resonance Spectroscopy, 2001, 39(1):1-40.
- [27]卢洁.不同环境因素胁迫下杂色鲍的代谢组学研究[D].厦门:厦门大学, 2016.
- [28]钟智明,陈家宇,张静,等.基于代谢组学分析光强胁迫对卵形鲳鲹代谢的影响[J].农业生物技术学报, 2022, 30(4):751-761.
- [29]刘佳琳.镉和砷对褐牙鲆幼鱼毒理效应的组学研究[D].烟台:中国科学院烟台海岸带研究所, 2017.
- [30]陈海红.不同生长环境的中华绒螯蟹营养品质、代谢组学和肠道微生物差异研究[D].上海:上海海洋大学,2021.
- [31] XIAO J, LI Q Y, TU J P, et al. Stress response and tolerance mechanisms of ammonia exposure based on transcriptomics and metabolomics in Litopenaeus vannamei[J]. Ecotoxicology and Environmental Safety, 2019, 180:491-500.
- [32] SHEN G P, DING Z N, DAI T, et al. Effect of dietary taurine supplementation on metabolome variation in plasma of Nile tilapia[J]. Animal, 2021, 15(3):100167.
- [33] SHEN G P, WANG S H, DONG J Y, et al. Metabolic effect of dietary taurine supplementation on grouper(Epinephelus coioides):a 1H-NMR-based metabolomics study[J]. Molecules,2019, 24(12):2253.
- [34] SCHOCK T B, NEWTON S, BRENKERT K, et al. An NMR-based metabolomic assessment of cultured cobia health in response to dietary manipulation[J]. Food Chemistry,2012, 133(1):90-101.
- [35] SVALHEIM R A, AAS-HANSEN?, HEIA K, et al. Simulated trawling:exhaustive swimming followed by extreme crowding as contributing reasons to variable fillet quality in trawl-caught Atlantic cod(Gadus morhua)[J]. PLoS One, 2020, 15(6):e0234059.
- [36] LEFEVRE F, COS I, POTTINGER T G, et al. Selection for stress responsiveness and slaughter stress affect flesh quality in pan-size rainbow trout, Oncorhynchus mykiss[J]. Aquaculture, 2016, 464:654-664.
- [37]杨婷婷,刘俊荣,俞微微,等.活品流通过程中虾夷扇贝风味品质的变化[J].水产学报, 2015, 39(1):136-146.
- [38]刘悦朋,刘俊荣,徐昙烨.养殖鱼类的动物福利与产品品质[J/OL].水产学报:1-11[2023-06-28].http://kns.cnki.net/kcms/detail/31.1283.S.20230515.1447.002.html
- [39]刘慧慧,刘俊荣,田元勇,等.易逝期干露对菲律宾蛤仔活品净化及贮藏特性的影响[J].大连海洋大学学报,2019, 34(1):109-118.
- [40]冷寒冰,刘俊荣,衣鸿莉,等.红鳍东方鲀易逝期锁鲜处置对冰藏品质的延迟效应[J].水产学报, 2021, 45(6):958-970.
- [41]李亚烜,刘俊荣,刘洋,等.易逝期胁迫强度对虾夷扇贝活力可恢复性的影响[J].大连海洋大学学报, 2020, 35(5):733-740.
- [42] XU T Y, YI H L, LIU Y P, et al. Mechanism of freshness-lock during the quality determination period of farmed turbot Scophthalmus maximus revealed by foodomics[J]. Aquaculture, 2023, 572:739513.
- [43] TIAN Y Y, XU T Y, LI Y X, et al. An untargeted LC-MS metabolomics approach to the metabolic profiles of bottom cultured scallops(Mizuhopecten yessoensis)subjected to mechanical shock in early post-harvest handling[J]. Aquaculture, 2021, 533:736061.
- [44] XU T Y, LI Y X, TIAN Y Y, et al. Effects of post-harvest hypoxic stress on post-landing recovery of live scallops(Mizuhopecten yessoensis)revealed by untargeted metabolomics based on UPLC-Q-TOF-MS[J]. Food Control, 2021, 123:107671.
- [45]徐昙烨,田元勇,李亚烜,等.基于UPLC-MS方法的品质易逝期活品虾夷扇贝代谢组学研究[J].大连海洋大学学报, 2021, 36(4):637-645.
- [46]熊善柏.水产品保鲜储运与检验[M].北京:化学工业出版社, 2007.
- [47] GALLART-JORNET L, RUSTAD T, BARAT J M, et al.Effect of superchilled storage on the freshness and salting behaviour of Atlantic salmon(Salmo salar)fillets[J]. Food Chemistry, 2007, 103(4):1268-1281.
- [48] DELBARRE-LADRAT C, CHéRET R, TAYLOR R, et al.Trends in postmortem aging in fish:understanding of proteolysis and disorganization of the myofibrillar structure[J]. Critical Reviews in Food Science and Nutrition,2006, 46(5):409-421.
- [49] LIDBURY I, MURRELL J C, CHEN Y. Trimethylamine N-oxide metabolism by abundant marine heterotrophic bacteria[J]. Proceedings of the National Academy of Sciences of the United States of America, 2014, 111(7):2710-2715.
- [50]刘金洋.虾夷扇贝在活品流通过程中的代谢变化[D].大连:大连海洋大学, 2016.
- [51]吴梓宣,周大勇,黄万成,等.暂养净化过程中虾夷扇贝营养成分及脂质组成[J].大连工业大学学报, 2019, 38(5):313-320.
- [52]陈山乔.基于代谢组学的水产品物流相关技术研究[D].上海:上海海洋大学, 2016.
- [53] ARU V, PISANO M B, SAVORANI F, et al. Metabolomics analysis of shucked mussels’freshness[J]. Food Chemistry,2016, 205:58-65.
- [54] PIRAS C, SCANO P, LOCCI E, et al. Analysing the effects of frozen storage and processing on the metabolite profile of raw mullet roes using1H NMR spectroscopy[J].Food Chemistry, 2014, 159:71-79.
- [55] J??SKEL?INEN E, JAKOBSEN L M A, HULTMAN J,et al. Metabolomics and bacterial diversity of packaged yellowfin tuna(Thunnus albacares)and salmon(Salmo salar)show fish species-specific spoilage development during chilled storage[J]. International Journal of Food Microbiology,2019, 293:44-52.
- [56] NAIR R R, JOSHI N, BORICHA V P, et al. Monitoring metabolite change in ice stored ghol fish(Protonibea diacanthus)by using a1H NMR technique:identification of pyruvate as a spoilage marker[J]. Analytical Methods,2016, 8(39):7030-7033.
- [57] CHANG W C W, WU H Y, YEH Y, et al. Untargeted foodomics strategy using high-resolution mass spectrometry reveals potential indicators for fish freshness[J]. Analytica Chimica Acta, 2020, 1127:98-105.
- [58]杜颖琦,范丽莉,欧昌荣,等.鲭鱼发酵过程中挥发性风味成分与细菌种群演替的相关性研究[J].食品工业科技, 2022, 43(20):152-162.
- [59] LI R, SUN Z L, ZHAO Y Q, et al. Application of UHPLCQ-TOF-MS/MS metabolomics approach to investigate the taste and nutrition changes in tilapia fillets treated with different thermal processing methods[J]. Food Chemistry,2021, 356:129737.
- [60] ZHANG M X, WANG X C, LIU Y, et al. Isolation and identification of flavour peptides from Puffer fish(Takifugu obscurus)muscle using an electronic tongue and MALDITOF/TOF MS/MS[J]. Food Chemistry, 2012, 135(3):1463-1470.
- [61] MABUCHI R, ISHIMARU A, ADACHI M, et al. Taste evaluation of yellowtail(Seriola quinqueradiata)ordinary and dark muscle by metabolic profiling[J]. Molecules,2019, 24(14):2574.
- [62]娄永江,魏丹丹,陈超,等.运用代谢组学研究保鲜处理对坛紫菜小分子物质的影响[J].中国食品学报, 2016, 16(11):196-203.
- [63] MING T H, HAN J J, LI Y Y, et al. A metabolomics and proteomics study of the Lactobacillus plantarum in the grass carp fermentation[J]. BMC Microbiology, 2018, 18(1):1-13.
- [64] WANG Y Q, LI C S, LI L H, et al. Application of UHPLCQ/TOF-MS-based metabolomics in the evaluation of metabolites and taste quality of Chinese fish sauce(Yu-lu)during fermentation[J]. Food Chemistry, 2019, 296:132-141.