叶景雯,姜双城,钟崇铭,潘文涛,林琪

• 1:福建农林大学海洋学院
• 2:福建水产研究所
• 3:汕头大学海洋灾害预警与防护广东省重点实验室

摘要(Abstract)：

【目的】综述转录组学技术的发展历程、转录组学在海洋生物毒理学中的研究进展及存在问题，为转录组学在微塑料胁迫下海洋生物分子层面上的毒理效应和机理机制研究领域更为广泛与高效的应用提供参考。【方法】在阐述转录组学发展历程及其在海洋生物毒理学应用的基础上，综述转录组学在鱼类、贝类、藻类和甲壳类毒理学上的研究进展；概括微塑料胁迫下海洋生物体内基因与蛋白质转录本的变化，并对转录组学在海洋生物毒理学的应用前景进行展望。【结果】利用转录组学技术阐明海洋生物体内微塑料毒性作用机制，研究发现微塑料会对海洋生物的免疫功能、代谢功能和生长发育方面的基因和蛋白表达都造成显著影响。但是在后续研究中仍需丰富海洋生物基因信息组信息，加强低浓度微塑料胁迫下海洋生物全周期毒理学研究与微塑料联合毒性研究。【结论】转录组学主要是从分子水平上研究基因表达情况，已是目前海洋生物毒理学研究领域的重要工具。

关键词(KeyWords)： 转录组学;微塑料;海洋环境;生态毒理

Abstract:

Keywords:

基金项目(Foundation): 福建省公益专项（2020R1013001）;; 福建省海洋服务与高质量发展专项（FJHY-YYKJ-2022-1-2、FJHY-HYYJ-2023-1、FJHYYYKJ-2023-1-1）;; 福建省海洋发展补助资金专项（FJHJF-L-2022-13）;; 科技部重点专项（SQ2020YFF0426577）

作者(Author): 叶景雯,姜双城,钟崇铭,潘文涛,林琪

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