徐静,邹仁健,陈红军,温珍昌

• 1:海南大学化学工程与技术学院
• 2:海南省精细化工工程技术研究中心
• 3:海南大学理学院

摘要(Abstract)：

【目的】综述红树林来源放线菌的生物多样性，及其代谢的抗菌活性产物方面的主要研究成果，为红树林放线菌资源以及抗生素类先导物的开发和应用奠定基础。【方法】在阐述红树林来源放线菌的生物多样性及其抗菌活性代谢产物的基础上，综述红树林放线菌的来源、鉴定方法、分布科属、优势菌属，并概括了红树林放线菌来源抗菌活性成分的结构类型、抗菌活性谱、最小抑菌浓度和产业应用前景。【结果】红树林地处热带和亚热带陆地与海洋之间的过渡地区，微生物资源极其丰富，2014年以来分离出上千株放线菌绝大多数来自于土壤，分布于35科96属，其中链霉菌和小单孢菌属为优势菌属，描述化合物73个，结构类型涉及生物碱、大环内脂类、萜类、酚类、黄酮类、肽类，其中34个是自2014年以来发现的并对该领域存在的问题和今后研究策略提出了建议。【结论】红树林放线菌在医药、农业及食品行业中具有广阔的应用前景，是获得新型抗生素类次生代谢产物的重要资源。

关键词(KeyWords)： 红树林放线菌;生物多样性;抗菌活性;代谢产物

Abstract:

Keywords:

基金项目(Foundation): 海南省重大科技项目(ZDKJ202008/ZDKJ202018);; 海南省重点研发项目（ZDYF2021108）;; 国家自然科学基金项目(81973229/82160675);; 广东省海洋药物重点实验室开放课题（LMM2021-4）

作者(Author): 徐静,邹仁健,陈红军,温珍昌

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