梁燕秋,司徒艳结,董忠典,许文强,梁杏仪,景占鑫

• 1:广东海洋大学化学与环境学院
• 2:广东海洋大学水产学院

摘要(Abstract)：

【目的】研究孕激素炔诺酮对斑马鱼(Danio rerio)肠道免疫调节因子的干扰效应。【方法】将成年斑马鱼分别在含0、7、84和810ng/L炔诺酮的水环境中暴露90d,分析炔诺酮对斑马鱼肠道组织中核转录因子κB(NF-κB),细胞因子α干扰素(IFN-α)、白细胞介素1α(IL-1α)、白细胞介素1β(IL-1β)、肿瘤坏死因子α(TNF-α)等含量的影响。【结果】炔诺酮主要在810 ng/L时显著提高雌鱼肠道组织中IFN-α、IL-1α和TNF-α含量,以及雄鱼肠道组织中NF-κB、IFN-α、IL-1α、IL-1β和TNF-α含量。【结论】炔诺酮可激活斑马鱼肠道组织中NF-κB信号通路,促进细胞因子的分泌,从而诱导斑马鱼肠道发生炎症反应。

关键词(KeyWords)： 斑马鱼;肠道免疫;炔诺酮;孕激素;干扰;细胞因子;核转录因子κB

Abstract:

Keywords:

基金项目(Foundation): 广东省自然科学基金项目(2017A030310662);; 国家自然科学基金项目(41907346);; 广东海洋大学科研启动费资助项目(R17075);; 广东海洋大学2019年度大学生创新训练项目(CXXL2019304)

作者(Author): 梁燕秋,司徒艳结,董忠典,许文强,梁杏仪,景占鑫

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