李玉玉,张才,薛红莎,刘白平,张永平,宋采

• 1:广东海洋大学食品科技学院

摘要(Abstract)：

利用慢性不可预知轻度应激诱导大鼠抑郁模型,以体质量、糖水偏好和旷场实验作为抑郁样行为评价指标,以腹腔巨噬细胞吞噬能力、皮质酮激素水平为外周免疫和应激激素指标,测定脑内多不饱和脂肪酸(PUFAs)探讨脑内细胞膜组成的变化。结果表明:与对照组相比,应激组大鼠在体质量、糖水偏好及旷场实验中穿越格数和站立次数均有明显下降,而皮质酮激素和腹腔巨噬细胞吞噬能力均显著增加,脑内n-3 PUFAs、n-3/n-6 PUFAs减少,喂饲EPA可显著改善应激引起的变化。

关键词(KeyWords)： EPA;不饱和脂肪酸;炎症;抑郁症;慢性不可预知性轻度应激

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(81471223,81171118)

作者(Author): 李玉玉,张才,薛红莎,刘白平,张永平,宋采

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