丙脒盐酸盐的合成工艺研究Synthesis of Propionamidine Hydrochloride
欧春艳,陈声宗
摘要(Abstract)：
采用单因子实验及均匀实验设计,考察了影响丙脒盐酸盐收率的因素,经回归分析,得出了合成丙脒盐酸盐的优化工艺条件:物料配比n(CH3CH2CN)﹕n(CH3OH)﹕n(HCl)=1﹕1.1﹕1.1;整个反应体系为无水体系;在反应前期,溶液温度为0~10℃,pH值为4.0左右,反应时间为9 h;在反应后期,溶液温度为0~20℃,pH值为8.0~8.5;氨-甲醇溶液的质量分数为15.0%。在此优化工艺条件下,丙脒盐酸盐的收率为94.0%,含量≥99%。
关键词(KeyWords)： 丙腈;丙脒盐酸盐;均匀实验设计;单因子实验
基金项目(Foundation):
作者(Author): 欧春艳,陈声宗
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