刘白平,李玉玉,张才,薛红莎,张永平,赵云涛,卢虹玉,宋采

• 1:广东海洋大学食品科技学院

摘要(Abstract)：

以Fat-1转基因小鼠和野生型C57BL/6小鼠为研究对象,经侧脑室注射脂多糖(lipopolysaccharide,LPS)诱导中枢炎症模型,测定抑郁样行为糖水偏好度和悬尾实验、腹腔巨噬细胞活性及其吞噬能力、脑炎症小胶质细胞的标记物CD11b基因与蛋白的表达水平,用以研究Fat-1对LPS诱发的炎症和抑郁样行为的作用。结果表明:在野生型小鼠中,LPS降低小鼠糖水偏好度,延长悬尾静止不动时间,增加腹腔巨噬细胞的活性和吞噬能力,上调CD11b基因和蛋白表达水平;而LPS不能引起Fat-1转基因小鼠出现上述类似变化。侧脑室注射LPS可引起野生型小鼠炎症反应和抑郁样行为,而Fat-1转基因小鼠可通过脑内和体内合成n-3 PUFAs抵抗LPS诱发的上述抑郁样变化。

关键词(KeyWords)： 抑郁症;Fat-1小鼠;LPS;炎症;n-3多不饱和脂肪酸

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(81171118,81471223);; 湛江市科技攻关计划项目“脑健康海洋药物与营养品重点实验室”

作者(Author): 刘白平,李玉玉,张才,薛红莎,张永平,赵云涛,卢虹玉,宋采

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