杨蓉,聂芳红,孔庆波,谢英明,林红英,陈进军

• 1:广东海洋大学农业生物技术研究所
• 2:广东海洋大学食品科技学院
• 3:中国刑事警察学院警犬技术系

摘要(Abstract)：

分别用25、50、100、200和400μg/L的3-甲基胆蒽(3-MC)对斑马鱼进行水浴染毒,于第7天和第14天采集各染毒组和对照组活鱼的肝、鳃、心、肠和肾,进行病理组织学检查。结果发现,一定剂量的3-MC能导致肝细胞变性,胞浆内出现脂肪滴,严重时肝细胞坏死解体,界限模糊;心肌细胞萎缩坏死;肠粘膜上皮细胞纹状缘不整齐,有的脱落;鳃丝结构异常,鳃小片表面粗糙,上皮细胞不完整;肾小管上皮细胞肿胀,细胞界限不清,管腔内均质红染。供试斑马鱼的病理组织变化与3-MC的作用剂量和作用时间存在一定的关系。

关键词(KeyWords)： 3-甲基胆蒽;毒性;病理组织学;斑马鱼

Abstract:

Keywords:

基金项目(Foundation): 广东省自然科学基金项目“几种DLCs对斑马鱼CYP1A的生化毒理学机理研究”(05011789);; 广东省国际合作项目“斑马鱼生物学标志CYP1A在DLCs环境污染监测中的应用研究”(2007B050200023)

作者(Author): 杨蓉,聂芳红,孔庆波,谢英明,林红英,陈进军

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